Bivalent hemagglutinin and neuraminidase influenza replicon particle vaccines protect pigs against influenza a virus without causing vaccine associated enhanced respiratory disease

Meghan Wymore Brand,Tavis K Anderson,Pravina Kitikoon,J Brian Kimble, Nicholas Otis,Phillip C Gauger,Carine K Souza,Bryan Kaplan,Mark Mogler,Erin Strait,Amy L Vincent Baker

Vaccine（2022）

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摘要

•HA and NA replicon particle vaccines induced high levels of peripheral and local antibody.•HA and NA replicon particle vaccines protected from homologous challenge.•HA replicon particle vaccines did not cause VAERD after heterologous challenge.•NA-matched replicon particle vaccine reduced replication of HA-mismatched virus in lungs.

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关键词

Influenza,Swine,Replicon particle,RNA vaccine,Vaccine Associated Enhanced Respiratory Disease (VAERD)

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