PYGBacking on glycogen metabolism to fuel early memory T cell recall responses

Joseph Longo,McLane J Watson,Matthew J Vos,Kelsey S Williams,Russell G Jones

Molecular Cell（2022）

引用 2|浏览11

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摘要

Zhang et al. (2022) show that TCR signaling promotes the phosphorylation and activation of glycogen phosphorylase B (PYGB) in CD8 memory T (Tmem) cells. PYGB-dependent glycogen mobilization provides a carbon source to support glycolysis and early Tmem cell recall responses.

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关键词

glycogen metabolism,memory,cell

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