Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition

Lu Jiang,Liying Xu,Lanzhi Zheng,Yuan Wang,Mingyang Zhuang,Dongdong Yang

Bioorganic & Medicinal Chemistry（2022）

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摘要

After modeling, salidroside was administrated on SD rats and HBE cells, which led to the up-regulation of PPP1R15A expression, thereby alleviating the ER stress of model rats and cells via down-regulating p-eIF-2α, GRP78, ATF4 and CHOP.

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关键词

Sepsis,Acute lung injury,Salidroside,Protein phosphatase 1 regulatory subunit 15A

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