Low normal FMR1 genotype in older adult women: Psychological well-being and motor function

Jessica Klusek, Roger Newman-Norlund,Amanda J. Fairchild, Sarah Newman-Norlund, Sara Sayers,Jill C. Stewart, Elizabeth Berry-Kravis,Julius Fridriksson

Archives of Gerontology and Geriatrics（2022）

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摘要

•Fewer-than-typical CGG repeats on FMR1 (e.g., “low normal”) may contribute to age-related health.•Older women with the low normal genotype show reduced motor function and psychological well-being.•FMR1 may be a potentially important but under-explored mediator of health in the aging population.•Larger epidemiological studies are needed.

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关键词

Age-related health,CGG repeat length,Balance,Dexterity,Healthy aging,Low zone CGGs,Fragile X-associated conditions

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