PARP1 inhibition elicits immune responses against non-small cell lung cancer

Pan Juncheng,Antoine Lafarge,Guido Kroemer,Maria Castedo

ONCOIMMUNOLOGY（2022）

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摘要

High levels of intracellular poly(ADP-ribose) (PAR) resulting from an elevated activity of PAR polymerase-1 (PARP1) correlate with poor infiltration of non-small cell lung cancers by cytotoxic T lymphocytes and dismal patient prognosis. Preclinical experimentation now demonstrates that PARP1 inhibition in cancer cells mediates strong immunostimulatory effects.

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关键词

Anticancer immune response, metabolism, tumor microenvironment, immune escape, non-small cell lung cancer

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