Immune hyporeactivity to bacteria and multiple TLR-ligands, yet no response to checkpoint inhibition in patients just after meeting Sepsis-3 criteria.

Alexandra Bick,Willem Buys,Andrea Engler,Rabea Madel, Mazen Atia, Francesca Faro,Astrid M Westendorf,Andreas Limmer,Jan Buer,Frank Herbstreit,Carsten J Kirschning,Jürgen Peters

PloS one（2022）

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摘要

Patients first meeting Sepsis-3 criteria reveal 1) depressed responses to multiple TLR-ligands, bacteria, and bacterial LPS, despite concomitant inflammation, but 2) no response to immune checkpoint inhibition.

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关键词

immune hyporeactivity,tlr-ligands

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