Intrapartum use of zidovudine in a large cohort of pregnant women living with HIV in Italy

Lucia Taramasso,Francesca Bovis,Antonio Di Biagio,Federica Mignone,Carlo Giaquinto,Claudia Tagliabue,Vania Giacomet,Orazio Genovese,Elena Chiappini,Serena Salomè,Raffaele Badolato,Ines Carloni,Monica Cellini,Icilio Dodi, Grazia Bossi, Alessandra Allodi,Stefania Bernardi,Rita Consolini,Maurizio Dedoni,Giuseppe Banderali

Journal of Infection（2022）

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摘要

•Peripartum HIV-RNA is the strongest factor influencing vertical transmission of HIV.•When HIV-RNA is <50 copies/mL, ART discontinuation is the strongest risk factor.•Intrapartum ZDV has no effect on transmission in women with HIV RNA <50 copies/mL.•The administration of unnecessary zidovudine may be perceived as a stigma.•Study of the U=U concept in mother-child couple could help fight stigma.

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关键词

HIV,vertical transmission,zidovudine,peripartum,U=U

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