Design and synthesis of multifunctional polymeric micelles for targeted delivery in Helicobacter pylori infection

•Hyaluronic acid-based block copolymer micelles for H. pylori infection were obtained.•HA-based nanomicelles showed important mucoadhesive and mucopenetrating properties.•The polymeric micelles are largely retained in gastric conditions, releasing the bioactive cargo.•The micelles were shown to highly penetrate in the mucus gasstric layer.•The present nanoformulation showed a high bioactivity both in vitro and in vivo against H. pylori infection.