The Fraction Size Sensitivity of Late Genitourinary Toxicity: Analysis of Alpha/Beta (α/β) Ratios in the CHHiP Trial

Douglas H. Brand,Sarah C. Brüningk,Anna Wilkins,Olivia Naismith,Annie Gao,Isabel Syndikus,David P. Dearnaley,Nicholas van As,Emma Hall,Sarah Gulliford,Alison C. Tree

International Journal of Radiation Oncology*Biology*Physics（2022）

引用 8|浏览7

暂无评分

摘要

Inclusion of EQD2-correction significantly improved model fitting for dysuria and hematuria endpoints, where fitted α/β ratio estimates were low: 0.6 to 2 Gy. This suggests therapeutic gain for clinician-reported GU toxicity, through hypofractionation, might be lower than expected by typical late α/β ratio assumptions of 3 to 5 Gy.

查看译文

关键词

Alpha/beta ratio,Prostate Cancer,Radiobiology,Radiotherapy,Toxicity

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要