Effect of pharmacological interventions and placebo on liver Histology in nonalcoholic steatohepatitis: A network meta-analysis

•By meta-analysis, the pooled rate of spontaneous NASH resolution without fibrosis worsening was 17%.•By meta-analysis, the pooled rate of spontaneous ≥1 stage reduction of fibrosis without worsening of NASH was 21%.•Meta-regression analysis showed that phase 3 vs phase 2 trials, older age and higher baseline AST levels were risk factors for more rapid histological progression.•By network meta-analysis Semaglutide and pioglitazone with/without Vitamin E had the highest probability of being the most effective therapeutic regimens for achieving NASH resolution without worsening of fibrosis.•By network meta-analysis aldafermin, lanifibranor and obethicolic acid had the highest probability of achieving ≥1 stage reduction of fibrosis without worsening of NASH.