Efficacy of adjunctive brexpiprazole on symptom clusters of major depressive disorder: A post hoc analysis of four clinical studies

•The study of symptom clusters could allow for individualized depression treatment.•Adjunctive brexpiprazole improves multiple symptom clusters in depression.•These include anhedonia, dysphoria, retardation, vegetative, interest, & lassitude.•Improvements appear early and are maintained over 6 weeks.