Amyloid- β and tau deposition influences cognitive and functional decline in Down syndrome

Monika Grigorova,Elijah Mak,Stephanie S G Brown,Jessica Beresford-Webb,Young T Hong,Tim D Fryer,Jonathan P Coles,Franklin I Aigbirhio,Dana Tudorascu,Annie Cohen,Bradley T Christian,Beau Ances,Benjamin L Handen,Charles M Laymon,William E Klunk,Isabel C H Clare,Anthony J Holland,Shahid H Zaman

Neurobiology of Aging（2022）

引用 4|浏览15

暂无评分

摘要

•Longitudinal analysis of tau and amyloid-β interaction in Down syndrome.•Tau as an independent predictor of cognitive and functional change.•Tau as a better predictor of cognitive and functional change than amyloid-β status.•Evidence that tau and amyloid-β contribute synergistically to cognitive decline.

查看译文

关键词

Down syndrome,Tau,Amyloid-β,PET [18F]-AV1451,PET [11C]PiB,Alzheimer's disease

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要