Endo-5-norbornene-2,3-dimethanol promoted asymmetric Heck/Suzuki cascade reaction of N-(2-bromophenyl)acrylamides

A highly enantioselective palladium-catalyzed Heck/Suzuki cascade reaction of N-(2-bromophenyl)acrylamides has been developed. Key to success of this transformation is that the endo-5-norbornene-2,3-dimethanol helps prevent transmetalation of aryl-palladium complex. The reaction...