Interleukin-36γ aggravates macrophage foam cell formation and atherosclerosis progression in ApoE knockout mice

Minghua Zhang,Jing Liu,Rong Gao,Yazhuo Hu,Li Lu,Chuanbin Liu,Lunna Ai,Jingkun Pan, Lei Tian,Jiao Fan

Cytokine（2021）

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摘要

•IL-36γ exacerbates atherosclerosis development in ApoE−/− mice.•RNA sequencing reveals that IL-36γ regulates the transcriptome of macrophages.•IL-36γ enhances foam cell formation and increases macrophage cholesterol accumulation.•IL-36γ modulates CD36 expression through PI3K pathway.

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关键词

Atherosclerosis,Interleukin-36γ,Macrophages,Foam cells

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