Toxoplasma gondii rhoptry protein (TgROP18) enhances the expression of pro-inflammatory factor in LPS/IFN-γ-induced murine BV2 microglia cells via NF-κB signal pathway

•TgROP18 induces the activated murine BV2 microglia cells to polarize to M1 phenotype.•TgROP18 upregulates the expression of pro-inflammatory factor in activated BV2 microglia cells via NF-κB signal pathway.•TgROP18 interacts with p65 and up-regulates its phosphorylation level at S536.