Chrysin alleviates lipopolysaccharide-induced neuron damage and behavioral deficits in mice through inhibition of Fyn

Qingchen Wang,Zhiping Yang,Xintong Wu,Xiao Zhang,Feng Geng,Qiaoyun Wang,Zikai Geng,Chen Yu,Zhipeng Li

International Immunopharmacology（2022）

引用 4|浏览3

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摘要

•Chrysin improved LPS-induced memory impair and depression-like behaviors in mice.•Chrysin attenuated LPS-induced neuron degeneration and synaptogenesis defects in mice.•Chrysin inhibited the activation of Fyn in BV2 cells and mouse brain tissue.•Chrysin inhibited NLRP3 inflammasome expression and NF-κB pathway via inhibition of Fyn.

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关键词

Chrysin,Neuroinflammation,Fyn,NF-κB,NLRP3

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