Investigating wound healing characteristics of gingival and skin keratinocytes in organotypic cultures

•Gingival junctional epithelium is recapitulated using a novel 3D organotypic method.•Gingival models re-epithelialize faster than skin in the 2D and 3D environment.•Gingival and skin models undergo different forms of migration.•Several genes related to wound healing are upregulated in gingiva compared to skin.•PITX1 could play role in superior oral wound healing.