Right Heart Failure in Mice Upon Pressure Overload Is Promoted by Mitochondrial Oxidative Stress

Marion Müller, Cornelius Bischof,Torben Kapries, Sophie Wollnitza, Chiara Liechty,Simon Geißen,Torben Schubert,Dragan Opacic,Muhammed Gerçek,Vera Fortmeier,Daniel Dumitrescu,Uwe Schlomann,Akylbek Sydykov,Aleksandar Petrovic,Leoni Gnatzy-Feik,Hendrik Milting,Ralph T. Schermuly,Kai Friedrichs,Volker Rudolph,Anna Klinke

JACC: Basic to Translational Science（2022）

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摘要

•Whereas the extent of RV structural remodeling is tightly linked to the degree of RV afterload, structural remodeling is dissociated from RHF•The transition of RV dysfunction to RHF is mediated by mitochondrial ROS•In contrast to 6N mice, 6J mice are protected from RHF upon RV pressure overload caused by reduced oxidative stress on account of genetic deficiency of the mitochondrial NNT•In patients with end-stage LHF, severely impaired RV function is associated with increased oxidative damage

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关键词

oxidative stress,pressure overload,pulmonary artery banding,reactive oxygen species,right heart failure

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