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Statins protect against early stages of doxorubicin-induced cardiotoxicity through the regulation of Akt signaling and SERCA2

Keith Dadson,Paaladinesh Thavendiranathan,Ludger Hauck,Daniela Grothe,Mohammed Ali Azam, Shanna Stanley-Hasnain,Donya Mahiny-Shahmohammady,Daoyuan Si,Mahmoud Bokhari,Patrick F.H. Lai,Stéphane Massé,Kumaraswamy Nanthakumar,Filio Billia

CJC Open（2022）

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摘要
Rosuvastatin counteracts the cardiotoxic effects of doxorubicin by directly targeting sarcoplasmic calcium cycling.
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