Type I photodynamic therapy with a self-degradable conjugated polyelectrolyte in combination with CpG adjuvant for cancer immunotherapy

•Self-degradable conjugated polyelectrolyte for controlled release of immune adjuvant (CpG) and excellent biocompatibility.•Aggregation-induced emission for enhanced photodynamic effect.•Type I photodynamic therapy for efficiency anti-hypoxia effect.•Combination of photodynamic therapy and immunotherapy for inhibiting metastatic cancer.