Management of death-related noncompleters in cluster randomized trials carried out in nursing homes: a methodological review

Pierre Poupin,Marie Ansoborlo, Agnès Caille,Clarisse Dibao-Dina, Bertrand Fougère,Bruno Giraudeau

Journal of Clinical Epidemiology(2022)

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摘要
•Trial discontinuations are frequent in cluster randomized trials performed in nursing homes.•It leads to a high proportion of noncompleters, essentially due to death.•Outcomes of noncompleters are essentially treated as noninformative missing data.•Such strategy is debatable.•It highlights the need for methodological and statistical improvement.
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关键词
Cluster randomized trials,Nursing homes,Noncompleters,Missing data,Statistical analysis,Geriatric
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