FoxP3 forkhead dimer: Don’t swap me now

Indra Bekere, Carina C. de Oliveira Mann

Immunity（2022）

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摘要

FoxP3 is critical for regulatory T cell function and, thus, overall immune homeostasis. In this issue of Immunity, Leng et al. reveal how FoxP3 achieves specific recognition of DNA and functional specialization by adopting a head-to-head domain conformation.

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