YMETA-ANALYSIS ADDRESSING THE EFFECT OF SODIUM-GLUCOSE CO-TRANSPORTER-2 INHIBITORS ON FLOW-MEDIATED DILATION IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Dimitrios Patoulias,Fotios Siskos,Alexandra Katsimardou,Konstantinos Imprialos,Konstantinos Koutsampasopoulos,Konstantinos Stavropoulos,Ioanna Zografou,Aristides Kefas,Christodoulos Papadopoulos,Michael Doumas

JOURNAL OF HYPERTENSION（2022）

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摘要

The present meta-analysis demonstrated a clear benefit on endothelial function with SGLT-2 inhibitors compared to placebo or active comparator. Although the sample size is small, it seems that amelioration of endothelial dysfunction with SGLT-2 inhibitors constitutes another significant mechanism that confers to cardio-protection with this drug class. Larger RCTs will shed further light on this important pathophysiologic link.

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关键词

diabetes mellitus,dilation,inhibitors,meta-analysis,sodium-glucose,co-transporter,flow-mediated

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