The aqueous extract of Phragmites rhizome improves hepatic steatosis in obese mice via the AMPK-mediated inhibition of ER stress

Tae Woo Jung,Yoon Hee Chung,Seung Yeon Park,Wonjun Cho,Heeseung Oh,Ahmet Hacimuftuoglu,A. M. Abd El-Aty,Joon Seok Bang,Ji Hoon Jeong

Journal of Functional Foods（2022）

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摘要

•The aqueous extract of Phragmites rhizome (AP) suppresses ER stress in hepatocytes under hyperlipidemic conditions.•AP ameliorates hepatic steatosis under hyperlipidemic conditions.•AMPK/autophagy signaling contribute to the effects of AP on impairment of hepatic lipid metabolism.

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关键词

Phragmites rhizome,Nonalcoholic fatty liver disease,Endoplasmic reticulum stress,AMP-activated protein kinase,Autophagy,Obesity

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