Synthesis of benzimidazole derivatives containing amide bond and biological evaluation as acetylcholinesterase, carbonic anhydrase I and II inhibitors

Zuhal Alim,Turgay Tunc,Nadir Demirel,Aslihan Guenel,Nurcan Karacan

Journal of Molecular Structure（2022）

引用 5|浏览4

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摘要

•Four benzimidazole derivatives containing amide bond (9a–10b) were synthesized.•Inhibitory effects of 9a–10b against AChE, hCA-I and hCA-II were investigated.•9a–10b had strong inhibitory effects on AChE, hCA-I and hCA-II at micromolar level.•Inhibition studies for 9a–10b were supported by molecular modeling.

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关键词

Acetylcholinesterase,Benzimidazole,Carbonic anhydrase,Inhibition,Molecular docking

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