Characterization, biological evaluation and molecular docking of a synthesised quinazolinone-based derivative

Journal of Molecular Structure(2022)

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摘要
•Synthesise of quinazoline derivative is described.•The obtained compound was characterized using several spectral analytical methods.•QD 5’s antibacterial performance was evaluated; it demonstrated interesting activity against several bacterial strains.•Docking studies indicated that there was conventional intermolecular hydrogen bonding between the active sites of the target enzymes and the docked molecules.
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关键词
Quinazolinone,Antibacterial,Spectral characterization,MD simulation,Docking,In vitro
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