Rhodium-catalyzed reaction of diazoquinones with allylboronates to synthesize allylphenols
Organic Chemistry Frontiers(2022)
摘要
Allylphenol is an important and ubiquitous structural motif in biologically active natural products and pharmaceuticals. Herein, we report a Rh2(esp)2-catalyzed reaction of diazoquinones with allylboronates, which provides access to a range of allylphenols, including para-allylphenols, ortho-allylphenols and allylnaphthols, in 44–94% yields and under mild conditions. The synthetic utility of the method was demonstrated by the short synthesis of two bioactive molecules. The mechanistic studies suggest that the reaction proceeds through a cyclopropanation/ring opening/aromatization pathway.
更多查看译文
关键词
allylboronates,allylphenols,diazoquinones,rhodium-catalyzed
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要