The putative NAD(P)H Nitroreductase, Rv3131, is the Probable Activating Enzyme for Metronidazole in Mycobacterium Tuberculosis.

Tuberculosis （TB）, which is caused by the intracellular pathogen, Mycobacterium tuberculosis（Mtb）, remains one of the deadliest infectious diseases worldwide, accounting for 1.45 million deaths in 2018 [1] . Thus, there is an increasing need to develop new antibiotics or to repurpose old drugs that have the potential to shorten the current duration of therapy.