A tyrosine catabolic intermediate 4-hydroxyphenylpyruate attenuates murine endotoxic shock by blocking NLRP3 inflammasome activation

Yanxia Wei,Mengnan Liu,Jinzhi Han, Haohan Huang,Shihong Xu,Shenghan Zhang,Qiyue Jing,Hanying Wang,Huimin Bu,Yanbo Kou,Zhuanzhuan Liu,Kuiyang Zheng,Yugang Wang

International Immunopharmacology（2022）

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摘要

•The serum level of 4-HPP was reduced in endotoxic shock in mice.•Blocking 4-HPP reduction by NTBC diminished LPS-induced sepsis.•Both 4-HPP and NTBC treatment prolonged mice survival in sepsis.•4-HPP, but not NTBC, inhibited macrophage NLRP3 inflammasome activation.•4-HPP inhibited NLRP3 inflammasome priming and activation processes.

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关键词

Inflammasome,Pyroptosis,4-HPP, metabolism,Macrophage,IL-1β,Immunometabolism

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