Sex-based Difference in Response to Recombinant Human Bone Morphogenetic Protein-2 in a Rat Posterolateral Fusion Model.

James P Foley,Elianna J Fred,Silvia Minardi,Jonathan T Yamaguchi,Allison C Greene,Andrew A Furman,Joseph G Lyons,Jonathan T Paul,Tejas S Nandurkar,Kenneth R Blank,Robert M Havey,Muturi Muriuki,Avinash G Patwardhan,Wellington K Hsu,Stuart R Stock,Erin L Hsu

Spine（2022）

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摘要

This study demonstrates sex-dependent differences in bone regeneration induced by rhBMP-2. Further investigation is needed to uncover the extent of and mechanisms underlying these sex differences, particularly at different doses of rhBMP-2.

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关键词

sex,sex-dependent differences,BMP,BMP-2,rhBMP-2,bone,regeneration,spine,spinal fusion,healing

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