Topology optimization based deterministic lateral displacement array design for cell separation

Hao Tang,Jiaqi Niu, Xinni Pan,Han Jin,Shujing Lin,Daxiang Cui

Journal of Chromatography A（2022）

引用 4|浏览5

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摘要

lA DLD separation chip with topology optimized pillar was developed.lA wide DLD channel to utilize altered zigzag mode.lLateral displacement of different sized cells is increased.lA homemade Dc constraint algorithm is derived.lNumerical, bead and cell experiments were carried out to show the high efficiency.

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关键词

Circulating tumor cell,Deterministic lateral displacement,Topology optimization,Pillar shape,Altered zigzag mode

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