Dextromethorphan improves locomotor activity and decreases brain oxidative stress and inflammation in an animal model of acute liver failure.

Mohammad Mehdi Ommati,Akram Jamshidzadeh,Mohsen Saeed,Mohammad Rezaei,Reza Heidari

Clinical and experimental hepatology（2022）

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摘要

The effect of dextromethorphan on oxidative stress and inflammation seems to be a major mechanism for its neuroprotective properties in HE. Based on these data DXM could be applied as an effective pharmacological option against HE-associated brain injury.

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关键词

ammonia,cognitive impairment,hepatic encephalopathy,liver failure,urea cycle

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