Enhancing neutralizing antibodies against receptor binding domain of SARS-CoV-2 by a safe natural adjuvant system

Maliheh Darvish,Zahra Moosavi-Nejad,Seyed Omid Ranaei Siadat,Fataneh Fatemi,Ali Khatibi

Virus Research（2023）

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摘要

•It is introduced a novel natural adjuvant for RBD-based vaccine for the first time.•Sodium alginate will increase the adsorption efficacy of alum to RBD Antigen.•Sodium alginate will increase the stability of recombinant vaccines, leading to enhancement of neutralizing antibody level.

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关键词

The receptor binding domain,Sodium alginate,Natural adjuvant,vaccine delivery,Surrogate virus neutralization test

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