Using time-weighted average change from baseline of SARS-CoV-2 viral load to assess impact of hydroxychloroquine as postexposure prophylaxis and early treatment for COVID-19

Raaka Kumbhakar,Moni Neradilek,Ruanne V Barnabas,Jenell Stewart,Helen C Stankiewicz Karita,Raphael J Landovitz,Patricia J Kissinger,Keith R Jerome,Michael K Paasche-Orlow,Anna Bershteyn,Helen Y Chu,Kathleen M Neuzil,Alexander L Greninger,Alfred Luk,Anna Wald,Elizabeth R Brown,Christine Johnston

Journal of Medical Virology（2022）

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摘要

Two randomized controlled trials demonstrated no clinical benefit of hydroxychloroquine (HCQ) for either postexposure prophylaxis or early treatment of SARS-CoV-2 infection. Using data from these studies, we calculated the time-weighted average change from baseline SARS-CoV-2 viral load and demonstrated that HCQ did not affect viral clearance.

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关键词

COVID-19, early treatment, hydroxychloroquine, PEP, SARS-CoV-2

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