Kramers Rate Theory of Pacemaker Dynamics in Noisy Excitable Media

Rhythmic activities, which are usually driven by pacemakers, are common in biological systems. In noisy excitable media, pacemakers are self-organized firing clusters, but the underlying dynamics remains to be elucidated. Here we develop a Kramers rate theory of coupled cells to describe the firing properties of pacemakers and their dependence on coupling strength and system size and dimension. The theory captures accurately the simulation results of tissue models with stochastic Hodgkin-Huxley equations except when transitions from pacemakers to spiral waves occur under weak coupling.