Methylene blue, Mycophenolic acid, Posaconazole, and Niclosamide inhibit SARS-CoV-2 Omicron variant BA.1 infection of human airway epithelial organoids

Romain Volle,Luca Murer,Anthony Petkidis,Vardan Andriasyan,Alessandro Savi,Cornelia Bircher, Nicole Meili, Lucy Fischer,Daniela Policarpo Sequeira,Daniela Katharina Mark,Alfonso Gomez-Gonzalez,Urs F. Greber

Current Research in Microbial Sciences（2022）

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摘要

•Methylene blue, mycophenolate, posaconazole and niclosamide inhibit SARS-CoV-2 VoC Omicron BA.1 infection of primary human airway organoids.•Inhibition occurs upon post-exposure drug treatment and without overt cell toxicity.•SARS-CoV-2 Omicron BA.1 infection of human airway organoids persists for at least three weeks without apparent cell lesion indicated by ORF1ab FISH staining of infected cells.

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关键词

SARS-CoV-2 variant of concern Omicron (BA.1),Drug repurposing,Methylene blue,Mycophenolic acid,Posaconazole,Niclosamide,Persistent infection,Human nasal and bronchial epithelial explant cultures

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