IL-4 receptor alpha signaling alters oral food challenge and immunotherapy outcomes in mice

Varsha Ganesan,Ankit Sharma,Sunil Tomar,Charles F Schuler,Simon P Hogan

Journal of Allergy and Clinical Immunology（2023）

引用 3|浏览8

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摘要

Collectively, these data indicate that single nucleotide polymorphisms in IL-4Rα can alter clinical symptoms of food allergic reactions, severity, and reactive dose during FC and OIT, and that severity of first reaction can predict the likelihood of reaction during FC in mice with IL-4Rα gain of function.

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IL-4Rα gain of function,food challenge,oral immunotherapy,biomarkers,genetics

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