Alpha-asarone ameliorates neurological deterioration of intracerebral hemorrhagic rats by alleviating secondary brain injury via anti-excitotoxicity pathways

Phytomedicine(2022)

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摘要
•ASA ameliorates short- and long-term neurological impairments of ICH rats.•ASA alleviates ICH-induced secondary brain injury via multi-facet targets.•ASA reduces astrocyte activation and consequent neuroinflammation.•ASA inhibits neuro-excitotoxicity induced by glutamate-related calcium cascades.•ASA suppresses mitochondrial-involved neuro-apoptosis and neuronal autophagy.
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关键词
Alpha-asarone,Intracerebral hemorrhage,Secondary brain injury,Glutamate-related cascades,Mitochondria-involved apoptosis,Inflammatory response
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