A high-level overview of the OECD AOP Development Programme.

Vinita Chauhan,Nobuyuki Hamada,Ruth Wilkins,Jacqueline Garnier-Laplace,Dominique Laurier,Danielle Beaton,Knut Erik Tollefsen

International journal of radiation biology（2022）

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摘要

Although the drivers for developing AOPs in chemical sector differ from that of the radiation field, the principles and transparency of the approach can benefit both scientific disciplines. By providing perspectives and an understanding of the evolution of the OECD AOP Development Programme including case examples and work toward quantitative AOP development, it may motivate the expansion and implementation of AOPs in the radiation field.

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关键词

OECD,adverse outcome,adverse outcome pathway,hazard assessment,key event,molecular initiating event,risk communication,risk management

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