cfDNA in maternal blood and Artificial Intelligence: Accurate Prenatal Detection of Fetal Congenital Heart Defects.

Ray Bahado-Singh,Perry Friedman,Ciara Talbot,Buket Aydas,Siddesh Southekal,Nitish K Mishra,Chittibabu Guda,Ali Yilmaz,Uppala Radhakrishna,Sangeetha Vishweswaraiah

American journal of obstetrics and gynecology（2022）

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摘要

We report for the first time the feasibility of minimally invasive detection of fetal CHD using AI and DNA methylation analysis of circulating cfDNA for the prediction of fetal CHD. Further, our findings support an important role of epigenetic changes in CHD development.

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关键词

Artificial Intelligence,Biomarkers,Congenital Heart Defect,DNA methylation,Precision cardiology,circulating cell-free DNA

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