Structural connectivity of the ANT region based on human ex-vivo and HCP data. Relevance for DBS in ANT for epilepsy

•We suspect that competing network (sub-) components are causative for the heterogeneous outcome of DBS for focal epilepsy when implanting “the ANT region”.•The high-resolution fiber atlas of the ANT region serves as basis for patient-specific whole brain modeling of such networks.•This work implements a synthetic pathway reconstruction method by combining anatomical fiber tracking with dMRI-based tractography.•Extended connectivity is based on the combination of structural, functional and topographic network features.•An anatomical high-resolution fiber map is introduced that represents the most important bundles related to the ANT region.•Our approach, based on microscale evaluation and assessment of neighborhood relations, optimizes the descriptive and predictive validity of parcellated structures.