Highly Divergent SARS-CoV-2 Alpha Variant in Chronically Infected Immunocompromised Person.

Emerging infectious diseases(2022)

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摘要
We detected a highly divergent SARS-CoV-2 Alpha variant in an immunocompromised person several months after the latest detection of the Alpha variant in the Netherlands. The patient was infected for 42 weeks despite several treatment regimens and disappearance of most clinical symptoms. We identified several potential immune escape mutations in the spike protein.
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Alpha variant,COVID-19,SARS-CoV-2,coronavirus disease,immunocompromised,respiratory infections,severe acute respiratory syndrome coronavirus 2,the Netherlands,variants,virus evolution,viruses,zoonoses
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