Differential requirement of Hippo cascade during CTNNB1 or AXIN1 mutation-driven hepatocarcinogenesis.

Binyong Liang,Haichuan Wang,Yu Qiao,Xue Wang,Manning Qian,Xinhua Song,Yi Zhou,Yi Zhang,Runze Shang,Li Che,Yifa Chen,Zhiyong Huang,Hong Wu,Satdarshan P Monga,Yong Zeng,Diego F Calvisi,Xiaoping Chen,Xin Chen

Hepatology (Baltimore, Md.)（2022）

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摘要

Our studies demonstrate that YAP/TAZ are major signaling molecules downstream of LOF AXIN1 mutant HCCs, and targeting YAP/TAZ is an effective treatment against AXIN1 mutant human HCCs.

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