Empagliflozin prohibits high-fructose diet-induced cardiac dysfunction in rats via attenuation of mitochondria-driven oxidative stress

Paramesha Bugga,Soheb Anwar Mohammed,Md Jahangir Alam,Parmeshwar Katare,Himanshu Meghwani,Subir Kumar Maulik,Sudheer Arava,Sanjay Kumar Banerjee

Life Sciences（2022）

引用 10|浏览5

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摘要

SGLT2 inhibitors show promising cardio-protection in the diabetic populace. However, the defending effect of SGLT2 inhibition in diabetes-associated cardiac complications and the molecular mechanism behind this effect are not thoroughly studied. Therefore, we aimed to investigate the effect of Empagliflozin, an SGLT2 inhibitor, in type-2 diabetic rat hearts.

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关键词

Empagliflozin,Palmitate,Oxidative stress,Insulin resistance,Mitochondrial dysfunction

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