The AAV-PCSK9 murine model of atherosclerosis and metabolic dysfunction.

William Coles Keeter, Nigeste M Carter,Jerry L Nadler,Elena V Galkina

European heart journal open（2022）

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摘要

High-fat diet with added cholesterol-fed AAV-PCSK9-injected C57BL/6 mice can serve as a useful model of integrated metabolic syndrome and atherosclerosis that does not require genetic manipulations.

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关键词

Atherosclerosis,Hypercholesterolaemia,Inflammation,Metabolic syndrome,Obesity

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