Characterizing intrinsic molecular features of the immune subtypes of salivary mucoepidermoid carcinoma

Hyundeok Kang,Mi-Kyoung Seo,BeumJin Park,Sun Och Yoon,Yoon Woo Koh,Dahee Kim,Sangwoo Kim

Translational Oncology（2022）

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摘要

•Immunophenotypically heterogeneous mucoepidermoid carcinoma (MEC) was profiled.•Lipid regulators were observed to play a role in MEC immunophenotype status.•immuno-oncological target genes may give new treatment options for MEC.•CRTC1-MAML2 fusion was observed to be not having immunogenic property in MEC.

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关键词

Salivary mucoepidermoid carcinoma,Immunophenotypic features,Tumor immune microenvironment,Lipid metabolism regulator,Immunotherapy

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