Palladium-Catalyzed Regio- and Stereoselective Coupling of Alkynylsulfones with Alkenes: Access to Dichlorinated Vinyl Sulfones
Organic Letters(2022)
摘要
A palladium-catalyzed coupling reaction of alkynylsulfones with alkenes has been described, which provides an efficient and practical entry to various functionalized dichlorinated vinyl sulfones. This method features excellent regio- and stereoselectivities, good functional group compatibility, as well as mild reaction conditions. Mechanistic studies suggest that the reaction goes through sequential syn-chloropalladation, alkene insertion, and C(sp3)–Cl bond formation processes, and the sulfonyl group is crucial to the stereoselectivity control of the reaction.
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关键词
alkynylsulfones,stereoselective coupling,alkenes,palladium-catalyzed
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