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The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression.

Irene Peñuelas-Haro,Rut Espinosa-Sotelo,Eva Crosas-Molist,Macarena Herranz-Itúrbide,Daniel Caballero-Díaz,Ania Alay,Xavier Solé,Emilio Ramos,Teresa Serrano,María L Martínez-Chantar,Ulla G Knaus,José M Cuezva,Antonio Zorzano,Esther Bertran,Isabel Fabregat

Hepatology (Baltimore, Md.)（2022）

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摘要
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC-dependent manner to promote HCC progression.
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