Remdesivir modifies interferon response in hospitalized COVID-19 patients.

Sarah L Murphy,Bente Halvorsen,Andreas Barratt-Due,Anne Ma Dyrhol-Riise,Pål Aukrust,Marius Trøseid,Tuva B Dahl

The Journal of infection（2022）

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摘要

•Remdesivir downregulates interferon responses in hospitalized COVID-19 patients.•Treatment had a particularly strong effect on interferon γ.•This response could be beneficial in mild, but not in severe disease.•Treatment options in COVID-19 could differ according to disease severity.

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