The H2O2 inherently released by the mycobacterial minor subpopulation enhances the survival of the major kin subpopulation against rifampicin

Rashmi Ravindran Nair,Deepti Sharan, Vijay Srinivasan,Nagaraja Mukkayyan, Kishor Jakkala,Parthasarathi Ajitkumar

Current Research in Microbial Sciences（2022）

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摘要

•Stress survival of mycobacterial minor (SCs) and major (NCs) subpopulations.•The SCs enhance survival of the NCs against rifampicin.•H2O2 released by the SCs increased KatG levels in the NCs.•Increased KatG levels neutralised the H2O2 formed during rifampicin exposure.•The enhanced survival was not observed in the furA-katG/katG knockout mutants.

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关键词

Mycobacteria,Bacterial subpopulations,Rifampicin,Isoniazid,H2O2,Antibiotic stress,Oxidative stress,Survival

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